|
KMID : 0032220100220030284
|
|
Annals of Dermatology
2010 Volume.22 No. 3 p.284 ~ p.289
|
|
|
The Immunohistochemical Patterns of the β-Catenin Expression in Pilomatricoma
|
|
Kim Young-Sik
Shin Dong-Hoon
Choi Jong-Soo
Kim Ki-Hong
|
|
|
Abstract
|
|
|
Background Pilomatricoma is a benign follicular tumor that is composed of basaloid cells, transitional cells and shadow cells. β-Catenin is a 92-kDa protein, and it plays important roles in cell-cell adhesion at the cell membrane and signal transduction in the nucleus. β-Catenin has recently been shown to play an important role in the formation of hair follicle-related tumors, including pilomatricoma. However, the pattern and the intracellular localization of the β-Catenin expression are still controversial.
Objective We wanted to evaluate the pattern and the intracellular localization of the β-Catenin expression in pilomatricoma by performing immunohistochemical staining.
Methods Twenty-seven paraffin-embedded tissue samples that were diagnosed as pilomatricoma were immunohistochemically stained with β-Catenin antibody.
Results Basaloid cells were found 15 samples of the total 27 pilomatricomas. All (15/15) of the basaloid cells strongly expressed β-Catenin, but the transitional cells and the shadow cells did not. In the basaloid cells, the nuclei and membranes showed prominent β-Catenin immunoreactivities, but the cytoplasm showed weak β-Catenin immunoreactivity.
Conclusion This study confirmed that the nucleus and membrane of all the basaloid cells in the pilomatricomas showed a strong β-Catenin expression, but the transitional cells and shadow cells showed negative β-Catenin immunoreactivity.
|
|
|
KEYWORD
|
|
|
β-Catenin, Immunohistochemical stain, Pilomatricoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|